Molecular and cellular insights into T cell exhaustion
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri3862.pdf
Reference149 articles.
1. Kaech, S. M. & Cui, W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat. Rev. Immunol. 12, 749–761 (2012).
2. Masopust, D. & Schenkel, J. M. The integration of T cell migration, differentiation and function. Nat. Rev. Immunol. 13, 309–320 (2013).
3. Wherry, E. J. T cell exhaustion. Nat. Immunol. 131, 492–499 (2011).
4. Doering, T. A. et al. Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory. Immunity 37, 1130–1144 (2012).This study shows that memory and exhausted CD8+ T cells have partially non-overlapping modules and centrally connected genes that are thought to be the hubs or foci of biological processes. This reference also indicates that transcription factors have distinct connections in exhausted CD8+ T cells compared with memory CD8+ T cells.
5. Schietinger, A. & Greenberg, P. D. Tolerance and exhaustion: defining mechanisms of T cell dysfunction. Trends Immunol. 35, 51–60 (2014).
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