Mechanistic Insights into the Capsule-Targeting Depolymerase from a Klebsiella pneumoniae Bacteriophage-Reference-Cited by-同舟云学术

Mechanistic Insights into the Capsule-Targeting Depolymerase from a Klebsiella pneumoniae Bacteriophage

Published:2021-09-03 Issue:1 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Dunstan Rhys A.¹²^ORCID,Bamert Rebecca S.¹²,Belousoff Matthew J.¹³,Short Francesca L.¹⁴⁵^ORCID,Barlow Christopher K.⁶,Pickard Derek J.⁵,Wilksch Jonathan J.¹²,Schittenhelm Ralf B.⁶,Strugnell Richard A.⁷^ORCID,Dougan Gordon⁵,Lithgow Trevor¹²^ORCID

Affiliation:

1. Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia

2. Centre to Impact AMR, Monash University, Clayton, Australia

3. Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

4. Wellcome Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

5. Department of Medicine, University of Cambridge, Cambridge, United Kingdom

6. Monash Proteomics & Metabolomics Facility, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

7. Department of Microbiology and Immunology, The Peter Doherty Institute, The University of Melbourne, Parkville, Australia

Abstract

Klebsiella pneumoniae is a medically important pathogen that produces a thick protective capsule that is essential for pathogenicity. Phages are natural predators of bacteria, and many encode diverse “capsule depolymerases” which specifically degrade the capsule of their hosts, an exploitable trait for potential therapies.

Funder

Australian Research Council

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01023-21

Reference87 articles.

1. Klebsiella spp. as Nosocomial Pathogens: Epidemiology, Taxonomy, Typing Methods, and Pathogenicity Factors

2. Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance inKlebsiella pneumoniae, an urgent threat to public health