ANT(9)-Ic, a Novel Chromosomally Encoded Aminoglycoside Nucleotidyltransferase from Brucella intermedia

Author:

Sheng Xiusheng12,Lu Wei2,Li Aifang3,Lu Junwan12,Song Chunhan1,Xu Jiefeng1,Dong Youming2,Fu Chunqing2,Lin Xi2,Zhu Mei4,Bao Qiyu12,Li Kewei2ORCID

Affiliation:

1. Medical Molecular Biology Laboratory, School of Medicine, Jinhua Polytechnic, Jinhua, China

2. Institute of Biomedical Informatics, Key Laboratory of Medical Genetics of Zhejiang Province, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China

3. Fifth Affiliated Hospital, Wenzhou Medical University, Lishui, Zhejiang, China

4. Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou, Zhejiang, China

Abstract

The emergence, evolution, and worldwide spread of antibiotic resistance present a significant global public health crisis. For aminoglycoside antibiotics, enzymatic drug modification is the most common mechanism of resistance.

Funder

NSFC | NSFC-Zhejiang Joint Fund | 浙江省科学技术厅 | Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

WMSTB | Basic Research Project of Wenzhou City

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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