Wollamide Cyclic Hexapeptides Synergize with Established and New Tuberculosis Antibiotics in Targeting Mycobacterium tuberculosis

Author:

Rollo Rachel F.1ORCID,Mori Giorgia1ORCID,Hill Timothy A.23ORCID,Hillemann Doris4,Niemann Stefan56ORCID,Homolka Susanne5ORCID,Fairlie David P.23ORCID,Blumenthal Antje1ORCID

Affiliation:

1. Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia

2. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

3. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

4. National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany

5. Molecular and Experimental Mycobacteriology, Priority Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany

6. German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany

Abstract

Tuberculosis (TB) is an infectious disease that affects millions of people globally, with 1.6 million deaths annually. TB treatment requires combinations of multiple different antibiotics for many months, and toxic side effects can occur.

Funder

U.S. Department of Defense

DHAC | National Health and Medical Research Council

Department of Education and Training | Australian Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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