Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition

Author:

Eger Elias1ORCID,Schwabe Michael1,Schulig Lukas2,Hübner Nils-Olaf3,Bohnert Jürgen A.4,Bornscheuer Uwe T.5,Heiden Stefan E.1ORCID,Müller Justus U.1,Adnan Fazal6,Becker Karsten4ORCID,Correa-Martinez Carlos L.7,Guenther Sebastian8,Idelevich Evgeny A.49,Baecker Daniel2,Schaufler Katharina110ORCID

Affiliation:

1. Pharmaceutical Microbiology, Institute of Pharmacy, University of Greifswald, Greifswald, Germany

2. Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Greifswald, Germany

3. Central Unit for Infection Prevention and Control, University Medicine Greifswald, Greifswald, Germany

4. Friedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany

5. Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Greifswald, Germany

6. Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan

7. Institute of Hygiene, University Hospital Münster, Münster, Germany

8. Pharmaceutical Biology, Institute of Pharmacy, University of Greifswald, Greifswald, Germany

9. Institute of Medical Microbiology, University Hospital Münster, Münster, Germany

10. Institute for Infectious Diseases, Christian Albrecht University and Schleswig-Holstein University Medical Center Kiel, Kiel, Germany

Abstract

Extensively drug-resistant Klebsiella pneumoniae causing major outbreaks and severe infections has become a significant challenge for health care systems worldwide. Rapid resistance development against last-resort therapeutics like ceftazidime-avibactam is a significant driver for the accelerated emergence of such pathogens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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