Mechanisms of IS <i>26</i> -Mediated Amplification of the <i>aphA1</i> Gene Leading to Tobramycin Resistance in an Acinetobacter baumannii Isolate-Reference-Cited by-同舟云学术

Mechanisms of IS 26 -Mediated Amplification of the aphA1 Gene Leading to Tobramycin Resistance in an Acinetobacter baumannii Isolate

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Harmer Christopher J.¹^ORCID,Lebreton Francois²^ORCID,Stam Jason²,McGann Patrick T.²,Hall Ruth M.¹^ORCID

Affiliation:

1. School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia

2. Multidrug Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

Abstract

Heteroresistance, a significant issue that is known to impact antibiotic treatment outcomes, is caused by the presence of spontaneously arising cells with elevated levels of resistance to therapeutically important antibiotics in a population of susceptible cells. Gene amplification is one well-documented cause of heteroresistance, but precisely how extensive amplification occurs is not understood.

Funder

Department of Health | National Health and Medical Research Council

Defense Medical Research and Development Program

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02287-22

Reference34 articles.

1. Transient antibiotic resistance calls for attention

2. Mechanisms and clinical relevance of bacterial heteroresistance