Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus-Reference-Cited by-同舟云学术

Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Antunes Daniela¹²,Gonçalves Samuel M.¹²,Matzaraki Vasiliki³,Rodrigues Cláudia S.¹²,Gonçales Relber A.¹²,Rocha Joana¹²,Sáiz Jorge⁴,Marques António⁵,Torrado Egídio¹²,Silvestre Ricardo¹²^ORCID,Rodrigues Fernando¹²^ORCID,van de Veerdonk Frank L.³,Barbas Coral⁴^ORCID,Netea Mihai G.³⁶,Kumar Vinod³⁷,Cunha Cristina¹²,Carvalho Agostinho¹²^ORCID

Affiliation:

1. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal

2. ICVS/3B’s—PT Government Associate Laboratory, Guimarães/Braga, Portugal

3. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands

4. Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo CEU, CEU Universities, Madrid, Spain

5. Serviço de Imuno-Hemoterapia, Hospital de Braga, Braga, Portugal

6. Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany

7. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Abstract

The fungal pathogen Aspergillus fumigatus can cause severe and life-threatening forms of infection in immunocompromised patients. The reprogramming of cellular metabolism is essential for innate immune cells to mount effective antifungal responses.

Funder

MEC | Fundação para a Ciência e a Tecnologia

EC | European Regional Development Fund

EC | Horizon 2020 Framework Programme

"la Caixa" Foundation

Gilead Research Scholars

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02256-22