Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Nonsusceptible Enterococcus faecium in a Simulated Endocardial Vegetation <i>Ex Vivo</i> Model-Reference-Cited by-同舟云学术

Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Nonsusceptible Enterococcus faecium in a Simulated Endocardial Vegetation Ex Vivo Model

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kunz Coyne Ashlan J.¹^ORCID,Stamper Kyle¹,El Ghali Amer¹^ORCID,Kebriaei Razieh¹^ORCID,Biswas Biswajit²^ORCID,Wilson Melanie²³,Deschenes Michael V.²³,Tran Truc T.⁴⁵^ORCID,Arias Cesar A.⁴⁵^ORCID,Rybak Michael J.¹⁶^ORCID

Affiliation:

1. Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA

2. Naval Medical Research Center–Frederick, Maryland, USA

3. Leidos, Reston, Virginia, USA

4. Division of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA

5. Center for Infectious Diseases, Houston Methodist Research Institute, Houston, Texas, USA

6. School of Medicine, Wayne State University, Detroit, Michigan, USA

Abstract

Our study supports the additional benefit of standard-of-care antibiotics combined with a phage cocktail compared to antibiotic alone against a daptomycin-nonsusceptible (DNS) E. faecium isolate in a high-inoculum simulated endocardial vegetation ex vivo PK/PD model. E. faecium is a leading cause of hospital-acquired infections and is associated with significant morbidity and mortality. Daptomycin is considered the first-line therapy for vancomycin-resistant E. faecium (VRE), but the highest published doses have failed to eradicate some VRE isolates.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00340-23

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