Targeting Aryl Hydrocarbon Receptor Signaling Enhances Type I Interferon-Independent Resistance to Herpes Simplex Virus

Author:

Chen Jincheng12,Liang Juan23,Xu Hui2,Liu Wenqi2,Liu Shuyan2,Duan Lian2,Li Fang2,Wang Zhaoqin2,Liu Yingxia2,McSharry Brian4ORCID,Feng Carl G.4,Zhang Guoliang24ORCID

Affiliation:

1. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

2. National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, The Third People’s Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, China

3. Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China

4. Infections, Immunity and Inflammation, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia

Abstract

This study describes how a virus might utilize host aryl hydrocarbon receptor signaling to promote its replication, even in the presence of type I interferons.

Funder

National Natural Science Foundation of China

National Key Research and Development Plan

Guangdong Scientific and Technological Foundation

Shenzhen Scientific and Technological Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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