In Vitro Roles of Burkholderia Intracellular Motility A (BimA) in Infection of Human Neuroblastoma Cell Line

Author:

Jitprasutwit Niramol1,Rungruengkitkun Amporn2,Lohitthai Sanisa2,Reamtong Onrapak3,Indrawattana Nitaya2,Sookrung Nitat45,Sricharunrat Thaniya6,Sukphopetch Passanesh2,Chatratita Narisara27,Pumirat Pornpan2ORCID

Affiliation:

1. Center for Vaccine Development, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand

2. Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

3. Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

4. Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

5. Biomedical Research Incubator Unit, Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

6. Pathology and Forensic Science Department, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand

7. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Abstract

Neurological melioidosis, caused by Burkholderia pseudomallei , can result in severe neurological damage and enhance the mortality rate of melioidosis patients. We investigate the involvement of the virulent factor BimA, which mediates actin-based motility, in the intracellular infection of neuroblastoma SH-SY5Y cells.

Funder

Mahidol University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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