SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA

Author:

Hofmann Samuel12,Plank Verena1,Groitl Peter1,Skvorc Nathalie1,Hofmann Katharina12,Luther Julius2,Ko Chunkyu13,Zimmerman Peter4,Bruss Volker3,Stadler Daniela13,Carpentier Arnaud5,Rezk Shahinda16,Nassal Michael4ORCID,Protzer Ulrike137ORCID,Schreiner Sabrina12378ORCID

Affiliation:

1. Institute of Virology, School of Medicine, Technical University of Munich, Germany

2. Institute of Virology, Hannover Medical School, Hannover, Germany

3. Institute of Virology, Helmholtz Zentrum München, Munich, Germany

4. Department of Internal Medicine II/Molecular Biology, University Hospital Freiburg, Freiburg, Germany

5. Institute of Experimental Virology, Twincore, Hannover, Germany

6. Medical Research Institute, Department of Molecular and Diagnostic Microbiology, Alexandria University, Alexandria, Egypt

7. German Center for Infection Research, Munich, Germany

8. Cluster of Excellence RESIST (Resolving Infection Susceptibility; EXC 2155), Hannover Medical School, Hannover, Germany

Abstract

HBV cccDNA is formed from the incomplete rcDNA involving several host DDR proteins. The exact process and the site of cccDNA formation are poorly understood.

Funder

DFG

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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