SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA-Reference-Cited by-同舟云学术

SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Hofmann Samuel¹²,Plank Verena¹,Groitl Peter¹,Skvorc Nathalie¹,Hofmann Katharina¹²,Luther Julius²,Ko Chunkyu¹³,Zimmerman Peter⁴,Bruss Volker³,Stadler Daniela¹³,Carpentier Arnaud⁵,Rezk Shahinda¹⁶,Nassal Michael⁴^ORCID,Protzer Ulrike¹³⁷^ORCID,Schreiner Sabrina¹²³⁷⁸^ORCID

Affiliation:

1. Institute of Virology, School of Medicine, Technical University of Munich, Germany

2. Institute of Virology, Hannover Medical School, Hannover, Germany

3. Institute of Virology, Helmholtz Zentrum München, Munich, Germany

4. Department of Internal Medicine II/Molecular Biology, University Hospital Freiburg, Freiburg, Germany

5. Institute of Experimental Virology, Twincore, Hannover, Germany

6. Medical Research Institute, Department of Molecular and Diagnostic Microbiology, Alexandria University, Alexandria, Egypt

7. German Center for Infection Research, Munich, Germany

8. Cluster of Excellence RESIST (Resolving Infection Susceptibility; EXC 2155), Hannover Medical School, Hannover, Germany

Abstract

HBV cccDNA is formed from the incomplete rcDNA involving several host DDR proteins. The exact process and the site of cccDNA formation are poorly understood.

Funder

DFG

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00446-23

Reference86 articles.

1. HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

2. Mechanism of Hepatitis B Virus cccDNA Formation

3. Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation