Lactobacillus rhamnosus HN001 Ameliorates BEZ235-Induced Intestinal Dysbiosis and Prolongs Cardiac Transplant Survival-Reference-Cited by-同舟云学术

Lactobacillus rhamnosus HN001 Ameliorates BEZ235-Induced Intestinal Dysbiosis and Prolongs Cardiac Transplant Survival

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Miao Xiaolong¹,Jiang Yuancong¹,Kong Deqiang¹,Wu Zelai¹,Liu Han¹,Ye Xiaolin²,Gong Weihua¹³^ORCID

Affiliation:

1. Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China

2. Städtisches Klinikum Wolfenbüttel, Wolfenbüttel, Federal Republic of Germany

3. Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China

Abstract

Our data confirmed that the combination of BEZ235 and Lactobacillus rhamnosus HN001 significantly prolongs cardiac transplant survival. A main metabolic product of Lactobacillus rhamnosus HN001, propionic acid (PA), enriches regulatory T (Treg) cells and serves as a potent immunomodulatory supplement to BEZ235. Our study provides a novel and efficient therapeutic strategy for transplant recipients.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00794-22

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