Orally Administered Lactobacillus rhamnosus CY12 Alleviates DSS-Induced Colitis in Mice by Restoring the Intestinal Barrier and Inhibiting the TLR4-MyD88-NF-κB Pathway via Intestinal Microbiota Modulation

Author:

Zheng Juanshan12ORCID,Ahmad Anum Ali13,Yang Chen1,Liang Zeyi1,Shen Wenxiang4,Liu Jing1,Yan Zuoting4,Han Jianlin56,Yang Yayuan4,Dong Pengcheng4,Lan Xianyong2,Salekdeh Ghasem Hosseini7ORCID,Ding Xuezhi14

Affiliation:

1. Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agricultural and Rural Affairs & Key Laboratory of Yak Breeding Engineering, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China

2. Laboratory of Animal Genome and Gene Function, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China

3. The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH8 9YL, U.K.

4. Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agricultural and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China

5. Livestock Genetics Program, International Livestock Research Institute (ILRI), 00100 Nairobi, Kenya

6. CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China

7. School of Natural Sciences, Macquarie University, North Ryde, New South Wales 2109, Australia

Funder

Innovation and Entrepreneurship Talent Project of Lanzhou

National Key Research and Development Program of China

Science Fund for Distinguished Young Scholars of Gansu Province

Natural Science Foundation of Gansu Province

Gansu Province

Publisher

American Chemical Society (ACS)

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