Prevalence and Genomic Characteristics of mcr -Positive Escherichia coli Strains Isolated from Humans, Pigs, and Foods in China

Author:

Lu Xiaoyu1ORCID,Zhang Pei23,Du Pengcheng45ORCID,Zhang Xiuli3,Wang Juan6,Yang Yingying7,Sun Honghu8ORCID,Wang Zhiqiang19ORCID,Cui Shenghui10,Li Ruichao19ORCID,Bai Li2

Affiliation:

1. Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China

2. Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People’s Republic of China, China National Center for Food Safety Risk Assessment, Beijing, China

3. Center for Disease Control and Prevention of Henan Province, Zhengzhou, China

4. Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

5. Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, China

6. College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China

7. Department of Neurology, Gaotang County People's Hospital, Gaotang, Shandong, China

8. Chengdu Institute for Food and Drug Control, Chengdu, China

9. Institute of Comparative Medicine, Yangzhou University, Yangzhou, Jiangsu, China

10. Department of Food Science, National Institutes for Food and Drug Control, Beijing, China

Abstract

The spread of polymyxin-resistant Enterobacteriaceae poses a significant threat to public health and challenges the therapeutic options for treating infections on a global level. In this study, mcr-1 -bearing ST10 E. coli was isolated from pigs, pork, and humans simultaneously, which demonstrated that ST10 E. coli was an important vehicle for the spread of mcr-1 among animals, foods, and humans.

Funder

National Natural Science Foundation of China

Postgraduate Research & Practice Innovation Program of Jiangsu Province

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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