Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016-Reference-Cited by-同舟云学术

Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016

Published:2016-07-07 Issue:27 Volume:21 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Xavier Basil Britto¹²³,Lammens Christine¹²³,Ruhal Rohit¹²³,Kumar-Singh Samir⁴¹³,Butaye Patrick⁵⁶⁷,Goossens Herman¹²³,Malhotra-Kumar Surbhi¹²³

Affiliation:

1. University of Antwerp, Wilrijk, Belgium

2. Vaccine & Infectious Disease Institute, Wilrijk, Belgium

3. Laboratory of Medical Microbiology, Wilrijk, Belgium

4. Molecular Pathology group, Cell Biology and Histology, Wilrijk, Belgium

5. Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis

6. CODA-CERVA, Brussels, Belgium

7. Ghent University, Faculty of Veterinary Medicine, Ghent, Belgium

Abstract

We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference29 articles.

1. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.;Liu;Lancet Infect Dis,2016

2. Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid.;Malhotra-Kumar;Lancet Infect Dis,2016

3. Complete sequence of an IncFII plasmid harbouring the colistin resistance gene mcr-1 isolated from Belgian pig farms.;Xavier;J Antimicrob Chemother,2016

4. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.;Bankevich;J Comput Biol,2012

Cited by 643 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Molecular Detection of Plasmid-mediated colistin-resistance genes in Multi-drug resistant Escherichia coli isolated from human and poultry in Duhok city, Iraq;Egyptian Journal of Veterinary Sciences;2024-03-01

2. Induction of proteome changes involved in the cloning of mcr-1 and mcr-2 genes in Escherichia coli DH5-α strain to evaluate colistin resistance;Journal of Global Antimicrobial Resistance;2024-03

3. Detection of mcr-1-1 Positive Enteropathogenic Escherichia coli Isolates Associated with Post-Weaning Diarrhoea in an Organic Piglet-Producing Farm in Austria;Microorganisms;2024-01-24

4. Blanket antimicrobial resistance gene database with structural information, BOARDS, provides insights on historical landscape of resistance prevalence and effects of mutations in enzyme structure;mSystems;2024-01-23

5. Occurrence of Mobile Colistin Resistance Genes mcr-1–mcr-10 including Novel mcr Gene Variants in Different Pathotypes of Porcine Escherichia coli Isolates Collected in Germany from 2000 to 2021;Applied Microbiology;2023-12-28