Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016-Reference-Cited by-同舟云学术

Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016

Published:2016-07-07 Issue:27 Volume:21 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Xavier Basil Britto¹²³,Lammens Christine¹²³,Ruhal Rohit¹²³,Kumar-Singh Samir⁴¹³,Butaye Patrick⁵⁶⁷,Goossens Herman¹²³,Malhotra-Kumar Surbhi¹²³

Affiliation:

1. University of Antwerp, Wilrijk, Belgium

2. Vaccine & Infectious Disease Institute, Wilrijk, Belgium

3. Laboratory of Medical Microbiology, Wilrijk, Belgium

4. Molecular Pathology group, Cell Biology and Histology, Wilrijk, Belgium

5. Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis

6. CODA-CERVA, Brussels, Belgium

7. Ghent University, Faculty of Veterinary Medicine, Ghent, Belgium

Abstract

We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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