Affiliation:
1. Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, United Kingdom
Abstract
Laboratory bacteriology involves the use of high-density cultures that we often assume to be clonal but that in reality are populations consisting of multiple genotypes at various abundances. We have demonstrated that the genetic structure of a single population of a widely used
Streptococcus pneumoniae
strain can be substantially altered by even short-term laboratory handling and culture and that, over time, this can lead to changes in virulence characteristics.
Funder
Microbiology Society
UKRI | Medical Research Council
Wellcome Trust
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology
Cited by
2 articles.
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