Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene-Reference-Cited by-同舟云学术

Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Allen Jawara¹,Rosendahl Huber Axel²³,Pleguezuelos-Manzano Cayetano⁴²,Puschhof Jens⁴²,Wu Shaoguang¹,Wu Xinqun¹,Boot Charelle⁴,Saftien Aurelia⁴,O’Hagan Heather M.⁵⁶⁷,Wang Hao⁸,van Boxtel Ruben²³,Clevers Hans⁴²³,Sears Cynthia L.¹⁹¹⁰¹¹^ORCID

Affiliation:

1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Oncode Institute, Utrecht, The Netherlands

3. The Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

4. Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands

5. Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana, USA

6. Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana, USA

7. Cell, Molecular and Cancer Biology Program, Indiana University School of Medicine, Bloomington, Indiana, USA

8. Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine Institutions, Baltimore, Maryland, USA

9. Department of Oncology, Johns Hopkins Medicine Institutions, Baltimore, Maryland, USA

10. Bloomberg-Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine Institutions, Baltimore, Maryland, USA

11. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine Institutions, Baltimore, Maryland, USA

Abstract

Many studies have shown that microbiome composition in both the mucosa and the stool differs in individuals with sporadic and hereditary colorectal cancer (CRC). Both human and mouse models have established a strong association between particular microbes and colon tumor induction.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01055-22

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5. Gut mucosal microbiome across stages of colorectal carcinogenesis

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