Disruption of Iron Homeostasis and Mitochondrial Metabolism Are Promising Targets to Inhibit Candida auris-Reference-Cited by-同舟云学术

Disruption of Iron Homeostasis and Mitochondrial Metabolism Are Promising Targets to Inhibit Candida auris

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Simm Claudia¹²,Weerasinghe Harshini¹²,Thomas David R.³,Harrison Paul F.⁴,Newton Hayley J.³^ORCID,Beilharz Traude H.⁵,Traven Ana¹²^ORCID

Affiliation:

1. Infection Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Victoria, Australia

2. Centre to Impact AMR, Monash University, Victoria, Australia

3. Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

4. Bioinformatics Platform, Monash University, Victoria, Australia

5. Development and Stem Cells Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Victoria, Australia

Abstract

Over the last decade, Candida auris has emerged as a human pathogen around the world causing life-threatening infections with wide-spread antifungal drug resistance, including pandrug resistance in some cases. In this study, we addressed the mechanism of action of the antiparasitic drug pyrvinium pamoate against C. auris and show how metabolism could be inhibited to curb C. auris proliferation.

Funder

Department of Health | National Health and Medical Research Council

Department of Education and Training | Australian Research Council

Monash-Warwick University Alliance AMR Training Program Fellowship

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00100-22

Reference75 articles.

1. Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision