Dose-Dependent Hepacivirus Infection Reveals Linkage between Infectious Dose and Immune Response-Reference-Cited by-同舟云学术

Dose-Dependent Hepacivirus Infection Reveals Linkage between Infectious Dose and Immune Response

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Gömer André¹²^ORCID,Delarocque Julien³^ORCID,Puff Christina⁴,Nocke Maximilian K.¹^ORCID,Reinecke Birthe⁵,Baumgärtner Wolfgang⁴,Cavalleri Jessika M. V.⁶,Feige Karsten³,Steinmann Eike¹^ORCID,Todt Daniel¹⁷^ORCID

Affiliation:

1. Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany

2. Institute of Virology, University of Veterinary Medicine Hannover, Hanover, Germany

3. Clinic for Horses, University of Veterinary Medicine Hannover, Hanover, Germany

4. Department of Pathology, University of Veterinary Medicine Hannover, Hanover, Germany

5. Institute of Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hanover, Germany

6. Clinical Section of Equine Internal Medicine, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria

7. European Virus Bioinformatics Center (EVBC), Jena, Germany

Abstract

We demonstrate that the EqHV dose of infection plays an important role for inducing immune responses, possibly linked to early clearance in high-dose and prolonged viremia in low-dose infections. In particular, pathways associated with innate and adaptive immune responses, as well as inflammatory responses, were more strongly upregulated in high-dose infections than in lower doses.

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01686-22

Reference58 articles.

1. ICTV Virus Taxonomy Profile: Flaviviridae

2. Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

3. Management of acute HCV infection in the era of direct-acting antiviral therapy

4. World Health Organization. 2017. Global hepatitis report 2017. WHO, Geneva, Switzerland.

5. Replication of hepatitis C virus;Bartenschlager R;J Gen Virol,2000

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