Molecular Determinants of Mouse Adaptation of Rat Hepacivirus-Reference-Cited by-全球学者库

Molecular Determinants of Mouse Adaptation of Rat Hepacivirus

Published:2023-04-27 Issue:4 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wolfisberg Raphael¹²^ORCID,Holmbeck Kenn¹²,Billerbeck Eva³⁴⁵,Thorselius Caroline E.¹²,Batista Mariana N.⁵,Fahnøe Ulrik¹²,Lundsgaard Emma A.¹²,Kennedy Matthew J.¹²,Nielsen Louise¹²,Rice Charles M.⁵,Bukh Jens¹²^ORCID,Scheel Troels K. H.¹²⁵^ORCID

Affiliation:

1. Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. CO-HEP, Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark

3. Department of Medicine, Division of Hepatology, Albert Einstein College of Medicine, New York, New York, USA

4. Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA

5. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, USA

Abstract

A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C virus infection impedes vaccine development as well as studies of immune responses and viral evasion.

Funder

EC | European Research Council

Sundhed og Sygdom, Det Frie Forskningsråd

Kræftens Bekæmpelse

Novo Nordisk Fonden

HHS | National Institutes of Health

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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