Genomics of Staphylococcus aureus and Staphylococcus epidermidis from Periprosthetic Joint Infections and Correlation to Clinical Outcome-Reference-Cited by-同舟云学术

Genomics of Staphylococcus aureus and Staphylococcus epidermidis from Periprosthetic Joint Infections and Correlation to Clinical Outcome

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Trobos Margarita¹²^ORCID,Firdaus Rininta¹²,Svensson Malchau Karin²³⁴,Tillander Jonatan²⁵⁶,Arnellos Dimitrios⁷,Rolfson Ola³⁴,Thomsen Peter¹^ORCID,Lasa Iñigo⁸^ORCID

Affiliation:

1. Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

2. Center for Antibiotic Resistance Research (CARe), University of Gothenburg, Gothenburg, Sweden

3. Department of Orthopedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

4. Department of Orthopaedics, Sahlgrenska University Hospital, Region of Västra Götaland, Gothenburg, Sweden

5. Department of Infectious Diseases, Sahlgrenska University Hospital, Region of Västra Götaland, Gothenburg, Sweden

6. Institute of Biomedicine, Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden

7. 1928 Diagnostics, Gothenburg, Sweden

8. Laboratory of Microbial Pathogenesis, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain

Abstract

This study addresses the presence and frequency of particular genetic variants and virulence factors found in staphylococcal bacteria causing periprosthetic joint infection (PJI) of the hip and knee to ascertain their clinical relevance as predictors of treatment failure. We characterized the genetic virulence traits of a large collection of clinical staphylococci isolated from patients with PJI and evaluated their association with the patient’s infection outcome.

Funder

European Union

CARe - Center for Antibiotic Resistance Research at University of Gothenburg

Swedish Research Council

Swedish government and the county councils

Västra Götalandsregionen

IngaBritt och Arne Lundbergs Forskningsstiftelse

Stiftelsen Handlanden Hjalmar Svenssons

Doktor Felix Neuberghs Stiftelse

Adlerbertska Stiftelserna

Sylvan Foundation

The Gothenburg Medical Society

Area of Advance Materials of Chalmers/GU Biomaterials

Spanish Ministry of Science, Innovation and Universities

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02181-21

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2. Deep prosthetic joint infection: a qualitative study of the impact on patients and their experiences of revision surgery

3. Infection triples the cost of a primary joint arthroplasty

4. Reflecting on and managing the emotional impact of prosthetic joint infections on orthopaedic surgeons—a qualitative study

5. The Not-So-Good Prognosis of Streptococcal Periprosthetic Joint Infection Managed by Implant Retention: The Results of a Large Multicenter Study

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