Multi-Omics Integration Reveals the Crucial Role of Fusobacterium in the Inflammatory Immune Microenvironment in Head and Neck Squamous Cell Carcinoma

Author:

Qiao Han1,Li Hui2,Wen Xianhui1,Tan Xirong1,Yang Chongzhe3,Liu Na1ORCID

Affiliation:

1. Department of Experimental Research, State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine; Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China

2. Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

3. Department of Geriatrics, National Key Clinic Specialty, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China

Abstract

Studies on revealing the composition and potential mechanisms of the tumor microbiome are still at an initial stage. We uncovered the potential contribution of the tumor-resident microbiota on the immunosuppressive microenvironment in HNSC, which will provide a new perspective for tumor microbiome research and yield valuable insights into the clinical management of HNSC.

Funder

Key Research and Development Program of Guangzhou City

China Postdoctoral Science Foundation

Guangzhou key Discipline of Medicine

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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