The microbiome and human cancer-Reference-Cited by-同舟云学术

The microbiome and human cancer

Published:2021-03-26 Issue:6536 Volume:371 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sepich-Poore Gregory D.¹^ORCID,Zitvogel Laurence²³⁴⁵^ORCID,Straussman Ravid⁶^ORCID,Hasty Jeff¹⁷⁸^ORCID,Wargo Jennifer A.⁹¹⁰^ORCID,Knight Rob¹¹¹¹²^ORCID

Affiliation:

1. Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.

2. Gustave Roussy Cancer Campus (GRCC), Equipe Labellisée–Ligue Nationale contre le Cancer, Villejuif, France.

3. Institut National de la Santé et de la Recherche Medicale (INSERM) U1015, Villejuif, France.

4. Université Paris-Sud, Université Paris-Saclay, Gustave Roussy, Villejuif, France.

5. Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France.

6. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

7. BioCircuits Institute, University of California, San Diego, La Jolla, CA, USA.

8. Molecular Biology Section, Division of Biological Science, University of California, San Diego, La Jolla, CA, USA.

9. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

10. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

11. Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.

12. Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.

Abstract

Separating microbes and cancers The role of microorganisms in causing and sustaining cancers has been in dispute for centuries. Through the lens of gut- and tumor-associated microbes, Sepich-Poore et al. review our current understanding of the microbiota in cancer, building a “microbially conscious” framework. The authors argue that humans should be considered as a meta-organism, but how our microbiota influences cancer is still not well understood mechanistically. Nevertheless, advances in microbiome research are improving our understanding of immuno-oncology and driving new diagnostic and therapeutic approaches. Science , this issue p. eabc4552

Funder

National Cancer Institute

RHU Torino Lumière

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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