A Matching Strategy To Guide Donor Selection for Ulcerative Colitis in Fecal Microbiota Transplantation: Meta-Analysis and Analytic Hierarchy Process

Author:

Zhang Bangzhou12ORCID,Yang Luxi1,Ning Hanbing3,Cao Man4,Chen Zhangran2,Chen Qiongyun2,Lian Guanghui5,Tang Hailing6,Wang Qizhi7,Wang Junping8,Lin Zhihui9,Wen Jianbo10,Liu Yuedong11,Xuan Ji12,Li Xuejun13,Lin Aiqiang4,He Jianquan2,Zhang Lei14,Hou Xiaohua14,Zeng Qiang15,Xiao Chuanxing41617

Affiliation:

1. School of Life Sciences, Xiamen University, Xiamen, China

2. School of Medicine, Xiamen University, Xiamen, China

3. Department of Digestive Diseases, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

4. Xiamen Treatgut Biotechnology Co., Ltd., Xiamen, China

5. Department of Gastroenterology, Xiangya Hospital, Changsha, China

6. Department of Gastroenterology, Xi'an Central Hospital, Xi’an, China

7. Department of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China

8. Department of Gastroenterology, The Affiliated People's Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

9. Department of Gastroenterology, Fujian Provincial Hospital, Fuzhou, China

10. Department of Gastroenterology, Pingxiang People’s Hospital, Pingxiang, China

11. Department of Gastroenterology, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

12. Department of Gastroenterology, Jinling Hospital, Nanjing, China

13. Department of Gastroenterology, The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China

14. Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Technology and Science, Wuhan, China

15. Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China

16. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China

17. Department of Gastroenterology, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China

Abstract

Modulation of gut microbiota by FMT from donors has been applied to the treatment of UC and yielded variable effectiveness in clinical trials. One possibility is that this variable effectiveness was related to donor selection, as a patient’s response to FMT may rely on the capability of the used donor’s microbiota to restore the specific gut disturbances of the patient.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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