Chinese guidelines for integrated diagnosis and treatment of intestinal microecology technologies in tumor application (2024 Edition)

Author:

Wang Qiang1,He Mingxin1,Liang Jing2,Tan Xiaohua3,Wu Qingming1,Wang Jun4,Li Xiaoan5,Qiao Mingqiang6,Huang Ziming7,Xie Qi2,Liu Zhe8,Ren Hua9,Wang Liang10,Zhou Hao11,Shao Liang12,Shu Rong13,Wu Wei14,Yang Wenyan15,Wang Hua16,Sun Zhiqiang17,Xu Xiaojun18,Zhang Xingding19,Li Zhiming20,Zhang Yu21,Meng Jingye22,Zhu Yanli23,Chen Feng24,Qu Rong25,Chen Peng26,Li Shuluan27,Shi Yuanyuan28,Mao Xin29,Hu Bichuan30,Zhang Yukui31,Cao Yu J.32,Guo Zhi32,

Affiliation:

1. Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan, China

2. Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, China

3. Department of Oncology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China

4. The University of Hong Kong-Shenzhen Hospital, Shenzhen, China

5. NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China

6. The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China

7. Hubei Maternal and Child Health Care Hospital, Wuhan, China

8. Medical College, Tianjin University, Tianjin, China

9. School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

10. Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

11. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

12. Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China

13. The Third People’s Hospital of Hubei Province, Wuhan, China

14. Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China

15. Shangdong First Medical University and Shangdong Academy of Medical Sciences, Jinan, China

16. Department of Hematology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China

17. Department of Hematology, Shenzhen Hospital, Southern Medical University, Shenzhen, China

18. Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China

19. The School of Medicine of Sun Yat-Sen University, Shenzhen, China

20. Medical Department, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China

21. Department of Hematology, Nanfang Hospital, Southern Medical University, Shenzhen, China

22. Department of Hematology and Oncology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China

23. The First Affliated Hosptial of Xinxiang Medical University, Xinxiang, China

24. The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

25. Department of Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou, China

26. Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China

27. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China

28. Shenzhen Cell Valley Biomedicine Co. LTD, Shenzhen, China

29. Primary Health Care Foundation of China, Xiangyang, China

30. Xiangyang Hospital of Integrated Traditional Chinese and Western Medicine, Xiangyang, China

31. Xiangyang Hospital of Traditional Chinese Medicine, Xiangyang, China

32. State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China

Abstract

ABSTRACT Intestinal microecology (IM) is the largest and most important microecological system of the human body. Furthermore, it is the key factor for activating and maintaining the physiological functions of the intestine. Numerous studies have investigated the effects of the gut microbiota on the different tissues and organs of the human body as well as their association with various diseases, and the findings are gradually being translated into clinical practice. The gut microbiota affects the occurrence, progression, treatment response, and toxic side effects of tumors. The deepening of research related to IM and tumors has opened a new chapter in IM research driven by methods and technologies such as second-generation sequencing and bioinformatics. The IM maintains the function of the host immune system and plays a pivotal role in tumor-control drug therapy. Increasing evidence has proven that the efficacy of tumor-control drugs largely depends on the IM balance, and strategies based on the IM technology show promising application prospects in the diagnosis and treatment of tumor. The Tumor and Microecology Professional Committee of the Chinese Anti-cancer Association gathered relevant experts to discuss and propose the “Chinese guidelines for integrated diagnosis and treatment of IM technologies in tumor application (2024 Edition),” which was established based on the research progress of the application of the IM technology in tumor to provide a basis for the standardization of the diagnosis and treatment of the IM technology in the tumor.

Publisher

Medknow

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