Identification of Small Molecule Inhibitors of the Pathogen Box against Vibrio cholerae-Reference-Cited by-同舟云学术

Identification of Small Molecule Inhibitors of the Pathogen Box against Vibrio cholerae

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kim Haeun¹²^ORCID,Burkinshaw Brianne J.¹²,Lam Linh G.¹²,Manera Kevin¹²,Dong Tao G.¹²³^ORCID

Affiliation:

1. Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

2. Biochemistry and Molecular Biology, Cumming School of Medicine, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

3. Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China

Abstract

Cholera is a serious infectious disease in tropical regions causing millions of infections annually. Vibrio cholerae , the causative agent of cholera, has gained multi-antibiotic resistance over the years, posing greater threat to public health and current treatment strategies. Here we report two compounds that effectively target the growth of V. cholerae and have the potential to control cholera infection.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Canada Research Chairs

Alberta Innovates - Health Solutions

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00739-21

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