Affiliation:
1. University of Illinois at Urbana-Champaign, Department of Pathobiology, Urbana, Illinois, USA
Abstract
An effective ETEC vaccine would prevent hundreds of millions of diarrhea clinical cases and save nearly 100,000 lives annually. MecVax, a protein-based injectable multivalent ETEC vaccine candidate, has been shown for the first time to induce functional antibodies against both ETEC enterotoxins (STa, LT) produced by all ETEC strains and seven ETEC adhesins (CFA/I, CS1 to CS6) expressed by ETEC strains causing a majority of ETEC diarrhea clinical cases and the moderate-to-severe cases.
Funder
HHS | National Institutes of Health
UofI | University of Illinois at Urbana-Champaign
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology
Cited by
10 articles.
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1. Mycosynthesis of CuO Nanoparticles Using
Aspergillus niger and Their Bioefficiency against Human Pathogens;Nano Biomedicine and Engineering;2024-06
2. Progress toward a vaccine for extraintestinal pathogenic
E. coli
(ExPEC) II: efficacy of a toxin-autotransporter dual antigen approach;Infection and Immunity;2024-05-07
3. MecVax supplemented with CFA MEFA-II induces functional antibodies against 12 adhesins (CFA/I, CS1–CS7, CS12, CS14, CS17, and CS21) and 2 toxins (STa, LT) of enterotoxigenic
Escherichia coli
(ETEC);Microbiology Spectrum;2024-04-02
4. Protein-based vaccine candidate MecVax broadly protects against enterotoxigenic
Escherichia coli
intestinal colonization in a rabbit model;Infection and Immunity;2023-11-16
5. A Polyvalent Adhesin–Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Escherichia coli Adhesins (CS7, CS12, CS14, CS17, and CS21) but Not Enterotoxins (LT and STa);Microorganisms;2023-10-01