The <i>cwp66</i> Gene Affects Cell Adhesion, Stress Tolerance, and Antibiotic Resistance in Clostridioides difficile-Reference-Cited by-同舟云学术

The cwp66 Gene Affects Cell Adhesion, Stress Tolerance, and Antibiotic Resistance in Clostridioides difficile

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhou Qingshuai¹,Rao Fengqin¹,Chen Zhenghong²^ORCID,Cheng Yumei³,Zhang Qifang¹,Zhang Jie⁴^ORCID,Guan Zhizhong¹,He Yan¹,Yu Wenfeng¹,Cui Guzhen²,Qi Xiaolan¹,Hong Wei¹^ORCID

Affiliation:

1. Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, China

2. Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Science, Guizhou Medical University, Guiyang, Guizhou, China

3. Department of Critical Care Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China

4. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China

Abstract

The cell wall protein 66 gene ( cwp66 ) encodes a cell wall protein, which is the second major cell surface antigen of C. difficile . Although immunological approaches, such as antibodies and purified recombinant proteins, have been implemented to study the role of Cwp66 in cell adhesion, no deletion mutant of the cwp66 gene has yet been characterized.

Funder

National Natural Science Foundation of China

NSFC | Joint Fund of the National Natural Science Foundation of China and the Karst Science Research Center of Guizhou Province

Natural Science Foundation of Guizhou Province

Guizhou Science and Technology Department

Department of Education of Guizhou Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02704-21