Whole-Genome Sequencing Reveals the High Nosocomial Transmission and Antimicrobial Resistance of Clostridioides difficile in a Single Center in China, a Four-Year Retrospective Study-Reference-Cited by-同舟云学术

Whole-Genome Sequencing Reveals the High Nosocomial Transmission and Antimicrobial Resistance of Clostridioides difficile in a Single Center in China, a Four-Year Retrospective Study

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wen Xin¹²,Shen Cong¹²³⁴^ORCID,Xia Jinyu⁵,Zhong Lan-Lan¹²,Wu Zhongwen⁶,Ahmed Mohamed Abd El-Gawad El-Sayed¹²⁷^ORCID,Long Nana⁸,Ma Furong⁹,Zhang Guili¹²,Wu Wenwei¹²,Luo Jianlve¹²,Xia Yong⁹,Dai Min⁸,Zhang Liyan¹⁰,Liao Kang⁶,Feng Siyuan¹²^ORCID,Chen Cha³⁴,Chen Yishen¹¹,Luo Wenji¹¹,Tian Guo-Bao¹²^ORCID

Affiliation:

1. Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

2. Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China

3. The Second Clinic Medical College, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China

4. Department of Clinical Laboratory, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, People’s Republic of China

5. Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, China

6. Department of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

7. Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), Cairo, Egypt

8. School of Laboratory Medicine, Chengdu Medical College, Chengdu, China

9. Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

10. Department of Clinical Laboratory, Guangdong Provincial People’s Hospital/Guangdong Academy of Medical Sciences, Guangzhou, China

11. Department of Pharmacy, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, China

Abstract

Clostridioides difficile infections (CDI) are the leading cause of healthcare-associated diarrhea and are known to be resistant to multiple antibiotics. In the past decade, C. difficile has emerged rapidly and has spread globally, causing great concern among American and European countries.

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Natural Science Foundation of Guangdong Province

111 project

Ministry of Education

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01322-21