Sequence Type 5 (ST5) as a Possible Predictor of Bacterial Persistence in Adult Patients with Methicillin-Resistant Staphylococcus aureus Pneumonia Treated with Vancomycin

Author:

Fan Ya-Xin123,Chen Meng-Ting123,Li Nan-Yang4,Liu Xiao-Fen123ORCID,Yang Min-Jie123,Chen Yuan-Cheng4ORCID,Liang Xiao-Yu123,Wu Ju-Fang1234,Guo Bei-Ning123,Song Si-Chao56,Zhu Yong-Qiang56,Zhang Feng-Ying7,Hang Jing-Qing7,Wu Sheng-Bin8,Shen Bo8,Li Hua-Yin9,Wang Qin9,Luo Xu-Ming10,Chen Qing-Ge10,Zhang Hui-Fang11,Wang Rui-Lan11,Shen Li-Hua1213,Fu Feng-Ming1213,Song Xiao-Lian14,Zhang Jing123ORCID

Affiliation:

1. Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China

2. Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai, China

3. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

4. Phase I Clinical Research Center, Huashan Hospital, Fudan University, Shanghai, China

5. Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human, Genome Center at Shanghai, Shanghai, China

6. Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China

7. Department of Pulmonary Medicine, Shanghai Putuo District People's Hospital, Shanghai, China

8. Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai, China

9. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China

10. Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

11. Emergency & Critical Care Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

12. Department of Critical Care, Fudan University Shanghai Cancer Center, Shanghai, China

13. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

14. Department of Respiratory and Critical Care Medicine, Tenth People's Hospital of Tongji University, Shanghai, China

Abstract

Few studies have simultaneously examined the influence of clinical characteristics of patients with pneumonia, the vancomycin pharmacokinetic/pharmacodynamic (PK/PD) index, and the phenotypic and genetic characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains. We assessed risk factors for vancomycin failure in patients with MRSA pneumonia by analyzing these influences in a prospective multicenter study.

Funder

Startup Research Fund of Huashan Hospital

Municipal Hospital Emerging Frontier Technology Joint Research Project of Shanghai Shenkang Development Center

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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