<i>Toxoplasma</i> TgAtg8-TgAtg3 Interaction Primarily Contributes to Apicoplast Inheritance and Parasite Growth in Tachyzoite-Reference-Cited by-同舟云学术

Toxoplasma TgAtg8-TgAtg3 Interaction Primarily Contributes to Apicoplast Inheritance and Parasite Growth in Tachyzoite

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Cheng Linyan¹,Tian Yuan²,Wang Yan²,Wang Tingting²,Yao Yinning²,Yu Helin¹,Zheng Xiaozi³,Wu Mimi²,Zhao Wei²,Hua Qianqian⁴,Hu Xin⁵,Tan Feng²^ORCID

Affiliation:

1. School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

2. Department of Parasitology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

3. Teaching Center of Morphological Experiment, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

4. Clinical Laboratory, Dongyang People's Hospital, Jinhua, Zhejiang, China

5. School of Medical Laboratory Science and School of Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China

Abstract

Toxoplasma gondii is a widespread intracellular parasite infecting a variety of warm-blooded animals, including humans. Current frontline treatment of toxoplasmosis suffers many drawbacks, including toxicity, drug resistance, and failure to eradicate tissue cysts, underscoring the need to identify novel drug targets for suppression or treatment of toxoplasmosis.

Funder

Natural Science Foundation of Zhejiang Province

NSFC | NSFC-Zhejiang Joint Fund | 浙江省科学技术厅 | Basic Public Welfare Research Program of Zhejiang Province

NSFC | NSFC-Zhejiang Joint Fund | 浙江省科学技术厅 | Zhejiang Xinmiao Talents Program

National Natural Science Foundation of China

Zhejiang Natural Science Funds for Distinguished Young Scientists

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01495-21