A Beta Strain-Based Spike Glycoprotein Vaccine Candidate Induces Broad Neutralization and Protection against SARS-CoV-2 Variants of Concern-Reference-Cited by-同舟云学术

A Beta Strain-Based Spike Glycoprotein Vaccine Candidate Induces Broad Neutralization and Protection against SARS-CoV-2 Variants of Concern

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Cao Lei¹,Guo Jinyuan¹,Li Hai¹,Ren Hu¹^ORCID,Xiao Kang¹,Zhang Yan¹,Zhu Shuangli¹,Song Yang¹,Zhao Weijia²,Wu Dan²,Chen Zhihui²,Zhang Yanan¹³,Xia Baicheng¹,Ji Tianjiao¹,Yan Dongmei¹,Wang Dongyan¹,Yang Qian¹,Zhou Yangzi¹,Li Xiaolei¹,Hou Zhanjun²,Xu Wenbo¹⁴

Affiliation:

1. NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

2. Hwellso Biotechnology (Beijing) Co., Ltd., Beijing, China

3. Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China

4. Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

Abstract

Continuous emergence of adaptive mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to challenge the use and development of existing vaccines and drugs. The value of variant-based vaccines that are capable of inducing a higher and broader protection immune response against SARS-CoV-2 variants is currently being evaluated.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02687-22

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