Loss of Pfizer (BNT162b2) Vaccine-Induced Antibody Responses against the SARS-CoV-2 Omicron Variant in Adolescents and Adults-Reference-Cited by-同舟云学术

Loss of Pfizer (BNT162b2) Vaccine-Induced Antibody Responses against the SARS-CoV-2 Omicron Variant in Adolescents and Adults

Published:2022-09-14 Issue:17 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gupta Sneh Lata¹²³,Mantus Grace¹²³,Manning Kelly E.¹²⁴,Ellis Madison¹²⁴,Patel Mit¹²⁴,Ciric Caroline Rose¹³,Lu Austin¹³,Turner Jackson S.⁵,O’Halloran Jane A.⁶,Presti Rachel M.⁷⁶,Joshi Devyani Jaideep¹²³,Ellebedy Ali H.⁵⁸⁷,Anderson Evan J.¹³⁹,Rostad Christina A.¹³,Suthar Mehul S.¹²³¹⁰⁴,Wrammert Jens¹²³

Affiliation:

1. Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA

2. Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA

3. Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Atlanta, Georgia, USA

4. National Primate Research Center, Atlanta, Georgia, USA

5. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

6. Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

7. Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, Missouri, USA

8. The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri, USA

9. Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

10. Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA

Abstract

While plasma binding and neutralizing antibody responses have been reported for cohorts of infected and vaccinated adults, much less is known about the vaccine-induced antibody responses to variants including Omicron in children. This illustrates the need to characterize vaccine efficacy in key vulnerable populations.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00582-22

Reference36 articles.

1. Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications