Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda-Reference-Cited by-同舟云学术

Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Byanyima Patrick¹,Kaswabuli Sylvia¹,Musisi Emmanuel²,Nabakiibi Catherine¹,Zawedde Josephine¹,Sanyu Ingvar¹,Sessolo Abdul¹,Andama Alfred¹³,Worodria William¹³,Huang Laurence⁴⁵,Davis J. Lucian⁶⁷^ORCID

Affiliation:

1. Infectious Diseases Research Collaboration, Kampala, Uganda

2. Division of Infection and Global Health, School of Medicine, University of St. Andrews, United Kingdom

3. Department of Internal Medicine, Makerere University College of Health Sciences, Kampala, Uganda

4. Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California, USA

5. Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, California, USA

6. Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA

7. Pulmonary, Critical Care, and Sleep Medicine Section, Yale School of Medicine, New Haven, Connecticut, USA

Abstract

Tuberculosis is among the leading causes of morbidity and mortality worldwide, in large part because >3 million people go undiagnosed and untreated each year. Sputum has been the mainstay for TB diagnosis for over a century but can be difficult for patients to produce.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00860-22

Reference28 articles.

1. World Health Organization. 2018. Global tuberculosis report 2018. World Health Organization, Geneva, Switzerland.

2. Xpert MTB/RIF and Xpert MTB/RIF Ultra for pulmonary tuberculosis and rifampicin resistance in adults

3. Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis

4. Cough Aerosols ofMycobacterium tuberculosisPredict New Infection. A Household Contact Study

5. World Health Organization. 2014. High priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting. World Health Organization, Geneva, Switzerland.

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