Longitudinal Variations in the <i>tprK</i> Gene of Treponema pallidum in an Amoy Strain-Infected Rabbit Model-Reference-Cited by-同舟云学术

Longitudinal Variations in the tprK Gene of Treponema pallidum in an Amoy Strain-Infected Rabbit Model

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Liu Dan¹²,Chen Rui²,He Yun²,Wang Yong-jing²,Lin Li-Rong¹²^ORCID,Liu Li-Li¹²^ORCID,Yang Tian-Ci¹²^ORCID,Tong Man-Li¹²

Affiliation:

1. Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, China

2. Institute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, China

Abstract

The tprK variations are an important factor in persistent T. pallidum infection. A nearly clonal isolate has been used previously to investigate the mechanism of tprK gene variations; however, clinical T. pallidum isolates in infected humans exhibit multiple heterogeneous tprK sequences.

Funder

MOST | National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

the Key Projects for Province Science and Technology Program of Fujian Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01067-23

Reference30 articles.

1. Identification of Treponema pallidum-specific protein biomarkers in syphilis patient serum using mass spectrometry