Complete Genome Sequence of
Treponema pallidum
, the Syphilis Spirochete
Author:
Fraser Claire M.1, Norris Steven J.1, Weinstock George M.1, White Owen1, Sutton Granger G.1, Dodson Robert1, Gwinn Michelle1, Hickey Erin K.1, Clayton Rebecca1, Ketchum Karen A.1, Sodergren Erica1, Hardham John M.1, McLeod Michael P.1, Salzberg Steven1, Peterson Jeremy1, Khalak Hanif1, Richardson Delwood1, Howell Jerrilyn K.1, Chidambaram Monjula1, Utterback Teresa1, McDonald Lisa1, Artiach Patricia1, Bowman Cheryl1, Cotton Matthew D.1, Fujii Claire1, Garland Stacey1, Hatch Bonnie1, Horst Kurt1, Roberts Kevin1, Sandusky Mina1, Weidman Janice1, Smith Hamilton O.1, Venter J. Craig1
Affiliation:
1. C. M. Fraser, O. White, G. G. Sutton, R. Dodson, M. Gwinn, E. K. Hickey, R. Clayton, K. A. Ketchum, S. Salzberg, J. Peterson, H. Khalak, D. Richardson, T. Utterback, L. McDonald, P. Artiach, C. Bowman, M. D. Cotton, C. Fujii, S. Garland, B. Hatch, K. Horst, K. Roberts, M. Sandusky, J. Weidman, H. O. Smith, and J. C. Venter are with The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. S. J. Norris, G. M. Weinstock, E. Sodergren, J. M. Hardham, M. P. McLeod, J. K....
Abstract
The complete genome sequence of
Treponema pallidum
was determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. The number of identifiable transporters is small, and no phosphoenolpyruvate:phosphotransferase carbohydrate transporters were found. Potential virulence factors include a family of 12 potential membrane proteins and several putative hemolysins. Comparison of the
T. pallidum
genome sequence with that of another pathogenic spirochete,
Borrelia burgdorferi
, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenic spirochetes.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference102 articles.
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