Involvement of a Phage-Encoded Wzy Protein in the Polymerization of K127 Units To Form the Capsular Polysaccharide of Acinetobacter baumannii Isolate 36-1454-Reference-Cited by-同舟云学术

Involvement of a Phage-Encoded Wzy Protein in the Polymerization of K127 Units To Form the Capsular Polysaccharide of Acinetobacter baumannii Isolate 36-1454

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Arbatsky Nikolay P.¹,Kasimova Anastasiya A.¹,Shashkov Alexander S.¹,Shneider Mikhail M.²³,Popova Anastasiya V.⁴^ORCID,Shagin Dmitry A.⁵,Shelenkov Andrey A.⁵,Mikhailova Yuliya V.⁵,Yanushevich Yurii G.⁵,Hall Ruth M.⁶^ORCID,Knirel Yuriy A.¹,Kenyon Johanna J.⁷^ORCID

Affiliation:

1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

2. M. M. Shemyakin & Y. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

3. Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, Smolensk, Russia

4. State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow, Russia

5. Central Scientific Research Institute of Epidemiology, Moscow, Russia

6. School of Life and Environmental Sciences, University of Sydney, Sydney, Australia

7. Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia

Abstract

Bacteriophage therapy is an attractive innovative treatment for infections caused by extensively drug resistant Acinetobacter baumannii , for which there are few effective antibiotic treatments remaining. Capsular polysaccharide (CPS) is a primary receptor for many lytic bacteriophages, and thus knowledge of the chemical structures of CPS produced by the species will underpin the identification of suitable phages for therapeutic cocktails.

Funder

Russian Science Foundation

Department of Education and Training | Australian Research Council

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01503-21

Reference37 articles.

1. Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection