Specific Interaction of Novel Friunavirus Phages Encoding Tailspike Depolymerases with Corresponding Acinetobacter baumannii Capsular Types

Author:

Popova A. V.123ORCID,Shneider M. M.34,Arbatsky N. P.5,Kasimova A. A.5,Senchenkova S. N.5,Shashkov A. S.5,Dmitrenok A. S.5,Chizhov A. O.5,Mikhailova Y. V.6,Shagin D. A.7,Sokolova O. S.8,Timoshina O. Y.46,Kozlov R. S.3,Miroshnikov K. A.4,Knirel Y. A.5

Affiliation:

1. Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow Region, Russia

2. State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, Russia

3. Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, Smolensk, Russia

4. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

5. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

6. Central Scientific Research Institute of Epidemiology, Moscow, Russia

7. Pirogov Russian National Research Medical University, Moscow, Russia

8. Lomonosov Moscow State University, Moscow, Russia

Abstract

Acinetobacter baumannii , a nonfermentative, Gram-negative, aerobic bacterium, is one of the most significant nosocomial pathogens. The pathogenicity of A. baumannii is based on the cooperative action of many factors, one of them being the production of capsular polysaccharides (CPSs) that surround bacterial cells with a thick protective layer.

Funder

Russian Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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