Limited Recognition of Highly Conserved Regions of SARS-CoV-2

Author:

Swaminathan Srividhya12,Lineburg Katie E.1,Ambalathingal George R.1,Crooks Pauline1,Grant Emma J.34,Mohan Sonali V.25,Raju Jyothy1,Panikkar Archana1,Le Texier Laetitia1,Tong Zheng Wei Marcus6,Chew Keng Yih6,Neller Michelle A.1,Short Kirsty R.6,Gowda Harsha25,Gras Stephanie34,Khanna Rajiv12,Smith Corey12

Affiliation:

1. QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

2. Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia

3. Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia

4. Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

5. Cancer Precision Medicine Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

6. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia

Abstract

T cells play a critical role in protection against SARS-CoV-2. Despite being highly topical, the protective role of preexisting preexisting memory CD8 + T cells, induced by prior exposure to circulating common coronavirus strains, remains less clear.

Funder

Medical Research Future Fund

Australian Research Council

Department of Health | National Health and Medical Research Council

QIMR Berghofer Medical Research Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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