Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans-Reference-Cited by-同舟云学术

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Published:2020-10-02 Issue:6512 Volume:370 Page:89-94
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mateus Jose¹^ORCID,Grifoni Alba¹^ORCID,Tarke Alison¹^ORCID,Sidney John¹^ORCID,Ramirez Sydney I.¹²^ORCID,Dan Jennifer M.¹²^ORCID,Burger Zoe C.²^ORCID,Rawlings Stephen A.²^ORCID,Smith Davey M.²^ORCID,Phillips Elizabeth³^ORCID,Mallal Simon³^ORCID,Lammers Marshall¹^ORCID,Rubiro Paul¹^ORCID,Quiambao Lorenzo¹^ORCID,Sutherland Aaron¹^ORCID,Yu Esther Dawen¹^ORCID,da Silva Antunes Ricardo¹^ORCID,Greenbaum Jason¹^ORCID,Frazier April¹,Markmann Alena J.⁴^ORCID,Premkumar Lakshmanane⁵^ORCID,de Silva Aravinda⁵^ORCID,Peters Bjoern¹²^ORCID,Crotty Shane¹²^ORCID,Sette Alessandro¹²^ORCID,Weiskopf Daniela¹^ORCID

Affiliation:

1. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

2. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA.

3. Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA 6150, Australia.

4. Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

5. Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

Abstract

Preexisting immune response to SARS-CoV-2 Robust T cell responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus occur in most individuals with coronavirus disease 2019 (COVID-19). Several studies have reported that some people who have not been exposed to SARS-CoV-2 have preexisting reactivity to SARS-CoV-2 sequences. The immunological mechanisms underlying this preexisting reactivity are not clear, but previous exposure to widely circulating common cold coronaviruses might be involved. Mateus et al. found that the preexisting reactivity against SARS-CoV-2 comes from memory T cells and that cross-reactive T cells can specifically recognize a SARS-CoV-2 epitope as well as the homologous epitope from a common cold coronavirus. These findings underline the importance of determining the impacts of preexisting immune memory in COVID-19 disease severity. Science , this issue p. 89

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

University of California, San Diego

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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