Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO <sub>3</sub> -Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO ₃ -Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ersoy Selvi C.¹^ORCID,Gonçalves Barbara²³,Cavaco Gonçalo²³,Manna Adhar C.⁴^ORCID,Sobral Rita G.²³^ORCID,Nast Cynthia C.⁵⁶,Proctor Richard A.⁷⁸,Chambers Henry F.⁹,Cheung Ambrose⁴,Bayer Arnold S.¹⁶

Affiliation:

1. The Lundquist Institute, Torrance, California, USA

2. Laboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO, Applied Molecular Biosciences Unit, Department of Life Sciences, Nova School of Science and Technology, Universidade Nova de Lisboa, Caparica, Portugal

3. Associate Laboratory i4HB, Institute for Health and Bioeconomy, Nova School of Science and Technology, Universidade Nova de Lisboa, Caparica, Portugal

4. Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

5. Cedars-Sinai Medical Center, Los Angeles, California, USA

6. Geffen School of Medicine at UCLA, Los Angeles, California, USA

7. Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

8. Department of Medical Microbiology/Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

9. UCSF School of Medicine, San Francisco, California, USA

Abstract

MRSA is generally viewed as resistant to standard β-lactam antibiotics. However, a NaHCO 3 -responsive phenotype is observed in a substantial proportion of clinical MRSA strains in vitro , i.e., isolates which demonstrate enhanced susceptibility to standard β-lactam antibiotics (e.g., oxacillin) in the presence of NaHCO 3 .

Funder

Applied Molecular Biosciences Unit

HHS | National Institutes of Health

MEC | Fundação para a Ciência e a Tecnologia

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03422-22

Reference50 articles.

1. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America