Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip-Reference-Cited by-同舟云学术

Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Si Longlong¹,Bai Haiqing¹,Oh Crystal Yuri¹,Jin Lei¹,Prantil-Baun Rachelle¹,Ingber Donald E.¹²³^ORCID

Affiliation:

1. Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA

2. Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA

3. Vascular Biology Program and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

Abstract

The rapid evolution of viruses, such as influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is challenging the use and development of antivirals and vaccines. Studies of within-host viral evolution can contribute to our understanding of the evolutionary and epidemiological factors that shape viral global evolution as well as development of better antivirals and vaccines.

Funder

HHS | National Institutes of Health

DOD | Defense Advanced Research Projects Agency

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00257-21

Reference30 articles.

1. SARS-CoV-2 spike D614G change enhances replication and transmission

2. Influenza