Affiliation:
1. Department of Respiratory and Critical Care Medicine Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai 200433 P. R. China
2. Institute of Respiratory Medicine School of Medicine Tongji University Shanghai 200433 P. R. China
3. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China
4. Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 P. R. China
Abstract
AbstractThe challenge of the treatment of end‐stage lung disease poses an urgent clinical demand for lung tissue engineering. Over the past few years, various lung tissue‐engineered constructs are developed for lung tissue regeneration and respiratory pathology study. In this review, an overview of recent achievements in the field of lung tissue engineering is proposed. The introduction of lung structure and lung injury are stated briefly at first. After that, the lung tissue‐engineered constructs are categorized into three types: acellular, monocellular, and multicellular systems. The different bioengineered constructs included in each system that can be applied to the reconstruction of the trachea, airway epithelium, alveoli, and even whole lung are described in detail, followed by the highlight of relevant representative research. Finally, the challenges and future directions of biomaterials, manufacturing technologies, and cells involved in lung tissue engineering are discussed. Overall, this review can provide referable ideas for the realization of functional lung regeneration and permanent lung substitution.
Funder
Fundamental Research Funds for the Central Universities
Science and Technology Commission of Shanghai Municipality
National Science Fund for Distinguished Young Scholars
National Natural Science Foundation of China