Affiliation:
1. School of Life and Environmental Sciences, The University of Sydney, New South Wales, Australia
Abstract
Aminoglycosides are important therapeutic options for treatment of
Acinetobacter
infections. Here, we show that a little-known aminoglycoside resistance gene,
aac(6′)-Im
(
aacA16
), that confers amikacin, netilmicin, and tobramycin resistance has been circulating undetected for many years in a sublineage of
A. baumannii
global clone 2 (GC2), generally with a second aminoglycoside resistance gene,
aacC1
, which confers resistance to gentamicin.
Funder
DHAC | National Health and Medical Research Council
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology