Detection of Ganciclovir-Resistant Cytomegalovirus in a Prospective Cohort of Kidney Transplant Recipients Receiving Subtherapeutic Valganciclovir Prophylaxis-Reference-Cited by-同舟云学术

Detection of Ganciclovir-Resistant Cytomegalovirus in a Prospective Cohort of Kidney Transplant Recipients Receiving Subtherapeutic Valganciclovir Prophylaxis

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wong Diana D.¹²,van Zuylen Wendy J.¹²,Novos Talia³,Stocker Sophie⁴⁵⁶,Reuter Stephanie E.⁷,Au Jane¹,Foster Charles S. P.¹²^ORCID,Day Richard O.⁵⁶,Horvath Andrea R.³,Endre Zoltan⁸,Rawlinson William D.¹²⁹^ORCID

Affiliation:

1. Serology and Virology Division, NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia

2. School of Medical Sciences, Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia

3. Department of Chemical Pathology, New South Wales Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia

4. Sydney Pharmacy School, Faculty of Medicine & Health, The University of Sydney, Sydney, New South Wales, Australia

5. Department of Clinical Pharmacology & Toxicology, St Vincent’s Hospital, Sydney, New South Wales, Australia

6. St Vincent’s Clinical School, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia

7. UniSA Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia

8. Department of Nephrology, Prince of Wales Hospital, Sydney, New South Wales, Australia

9. School of Biotechnology and Biomolecular Sciences, University of New South Wales Sydney, Sydney, New South Wales, Australia

Abstract

This study examined the pharmacokinetics and viral genomic data from a prospective cohort of kidney transplant recipients undergoing valganciclovir prophylaxis for cytomegalovirus (CMV) prevention. We showed for the first time using high-throughput sequencing the detection of ganciclovir resistance mutations in breakthrough CMV infection during subtherapeutic plasma ganciclovir as indicated by the pharmacokinetic parameter daily area under the curve (AUC 24 ).

Funder

State Government Department of Health

Australian Government Medical Research Future Fund

CCA | Cancer Council South Australia

Department of Education, Skills and Employment, Australian Government

Deutscher Akademischer Austauschdienst

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02684-21