Current Perspectives on the Management of Herpesvirus Infections in Solid Organ Transplant Recipients

Author:

Malahe S. Reshwan K.12,van Kampen Jeroen J. A.3ORCID,Manintveld Olivier C.24ORCID,Hoek Rogier A. S.25ORCID,den Hoed Caroline M.26ORCID,Baan Carla C.12,Kho Marcia M. L.12ORCID,Verjans Georges M. G. M.37ORCID

Affiliation:

1. Department of Internal Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands

2. Erasmus MC Transplant Institute, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands

3. Department of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands

4. Department of Cardiology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands

5. Department of Pulmonary Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands

6. Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands

7. HerpeslabNL, Department of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands

Abstract

Solid organ transplant recipients (SOTRs) are at high risk of human herpesvirus (HHV)-related morbidity and mortality due to the use of immunosuppressive therapy. We aim to increase awareness and understanding of HHV disease burden in SOTRs by providing an overview of current prevention and management strategies as described in the literature and guidelines. We discuss challenges in both prevention and treatment as well as future perspectives.

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Reference194 articles.

1. (2023, May 01). Global Observatory on Donation and Transplantation. Available online: https://www.transplant-observatory.org/.

2. Solid organ transplantation in the 21(st) century;Black;Ann. Transl. Med.,2018

3. Infection in Organ Transplantation;Fishman;Am. J. Transplant.,2017

4. Herpesvirus infections in organ transplant recipients;Jenkins;Clin. Diagn. Lab. Immunol.,2003

5. Herpesviruses and Their Host Cells: A Successful Liaison;Adler;Trends Microbiol.,2017

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1. Skin and soft tissue infections in solid organ transplants;Current Opinion in Infectious Diseases;2023-12-05

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