Bean Extract-Based Gargle for Efficient Diagnosis of Active COVID-19 Infection Using Rapid Antigen Tests-Reference-Cited by-同舟云学术

Bean Extract-Based Gargle for Efficient Diagnosis of Active COVID-19 Infection Using Rapid Antigen Tests

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kwon Joseph¹²³,Ko Euna⁴,Cho Se-Young⁵,Lee Young-Ho²⁶⁷,Jun Sangmi⁷,Lee Kyuhong⁸⁹,Hwang Eunha¹,Vaidya Bipin⁵,Hwang Jeong-Hwan¹⁰,Hwang Joo-Hee¹⁰,Kim Namsu¹¹,Song Mi-Kyung⁸⁹,Kim Hye-Yeon⁷¹²,Ito Dai⁷¹³,Lin Yuxi⁷,Jo Eunae⁷,Yang Kyeong Eun¹,Chung Hee-Chung¹,Cha Soyoung¹,Kim Dong Im⁸,Yi Yoon-Sun⁷,Yun Sung-Ho¹,Park Sun Cheol⁷¹²,Lee Sangmin¹⁴,Choi Jong-Soon⁴,Kim Dal Sik¹¹,Kim Duwoon³⁵^ORCID

Affiliation:

1. Department of BioChemical Analysis, Korea Basic Science Institute, Daejeon, Republic of Korea

2. Bio-Analytical Science, University of Science and Technology, Daejeon, Republic of Korea

3. BIO3S, Inc., Gwangju, Republic of Korea

4. Research Center for Materials Analysis, Korea Basic Science Institute, Daejeon, Republic of Korea

5. Department of Food Science and Technology, Foodborne Virus Research Center, Chonnam National University, Gwangju, Republic of Korea

6. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea

7. Research Center for Bioconvergence Analysis, Korea Basic Science Institute, Daejeon, Republic of Korea

8. National Center for Efficacy Evaluation for Respiratory Disease Product, Korea Institute of Toxicology, Daejeon, Republic of Korea

9. Department of Human and Environmental Toxicology, University of Science and Technology, Daejeon, Republic of Korea

10. Department of Internal Medicine, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School and Hospital, Jeonju, Republic of Korea

11. Department of Laboratory Medicine, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School and Hospital, Jeonju, Republic of Korea

12. Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea

13. Department of Brain and Cognitive Science, Institute of Science and Technology (DGIST), Daegu, Republic of Korea

14. BioApplications Inc., Pohang, Republic of Korea

Abstract

An Ag-RDT is less likely to be accepted as an initial test method for early diagnosis owing to its low sensitivity. However, our self-collection method, Ag-RDT using BG-based saliva specimens, showed significantly enhanced detection sensitivity and specificity toward SARS-CoV-2 including the Alpha and Delta variants in all patients tested within 6 days of illness.

Funder

BIO3S, Inc.

Jeonbuk National University Hospital

Korea Basic Science Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01614-21

Reference38 articles.

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5. World Health Organization. 2020. Antigen-detection in the diagnosis of SARS-CoV-2 infection using rapid immunoassays: interim guidance. https://apps.who.int/iris/handle/10665/334253.

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