Regulation of Helicobacter pylori Urease and Acetone Carboxylase Genes by Nitric Oxide and the CrdRS Two-Component System-Reference-Cited by-同舟云学术

Regulation of Helicobacter pylori Urease and Acetone Carboxylase Genes by Nitric Oxide and the CrdRS Two-Component System

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Allen Madison G.¹,Bate Miranda Y.¹,Tramonte Lauren M.¹,Avalos Emely Y.¹,Loh John²,Cover Timothy L.²³⁴⁵^ORCID,Forsyth Mark H.¹^ORCID

Affiliation:

1. Department of Biology, College of William & Mary, Williamsburg, Virginia, USA

2. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

3. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

4. Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA

5. Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA

Abstract

The molecular strategies used by Helicobacter pylori to colonize and persist in the harsh environment of the human stomach are a critical area of study. Our study identified several genes in this gastric pathogen, including ureA , a gene encoding a protein essential to the survival of H. pylori , that are regulated via the CrdRS two-component system (TCS) in response to nitric oxide (NO).

Funder

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04633-22

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