Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in <i>Aspergillus fumigatus</i>-Reference-Cited by-同舟云学术

Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in Aspergillus fumigatus

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhao Shu¹²,Martin-Vicente Adela³,Colabardini Ana Cristina⁴,Pereira Silva Lilian⁴,Rinker David C.⁵,Fortwendel Jarrod R.³^ORCID,Goldman Gustavo Henrique⁴^ORCID,Gibbons John G.¹²⁶^ORCID

Affiliation:

1. Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts, USA

2. Department of Food Science, University of Massachusetts, Amherst, Massachusetts, USA

3. Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, Tennessee, USA

4. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

5. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA

6. Organismic and Evolutionary Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts, USA

Abstract

This is one of the first studies to apply genomewide association (GWA) analysis to identify genes involved in an Aspergillus fumigatus phenotype. A. fumigatus is an opportunistic fungal pathogen that causes hundreds of thousands of infections and ~100,000 deaths each year, and antifungal resistance has rapidly evolved in this species. A phenomenon called the caspofungin paradoxical effect (CPE) occurs in some isolates, where high concentrations of the drug lead to increased growth rate.

Funder

HHS | National Institutes of Health

Sao Paulo Research Foundation

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00519-22

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