Lovastatin biosynthesis in Aspergillus terreus: Characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene-Reference-Cited by-同舟云学术

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Lovastatin biosynthesis in Aspergillus terreus: Characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene

Published:1999-07 Issue:7 Volume:6 Page:429-439
ISSN:1074-5521
Container-title:Chemistry & Biology
language:en
Short-container-title:Chemistry & Biology

Author:

Hendrickson Lee,Ray Davis C,Roach Claudia,Kim Nguyen Di,Aldrich Teri,McAda Phyllis C,Reeves Christopher D

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference33 articles.

1. Mevinolin: a highly potent competetive inhibitor of hydroxymethyl-glutaryl-coenzyme A reductase and a cholesterol-lowering agent;Alberts,1980

2. Biosynthesis of the hypocholesterolemic agent mevinolin by Aspergillus terreus: determination of the origin of carbon, hydrogen and oxygen atoms by carbon-13 NMR and mass spectrometry;Moore;J. Am. Chem. Soc.,1985

3. Revision of the biosynthetic origin of oxygens in mevinolin (Lovastatin), a hypocholesterolemic drug from Aspergillus terreus MF 4845;Yoshizawa;J. Am. Chem. Soc.,1994

4. Biosynthesis of ML-236C and the hypocholesterolemic agents compactin by Penicillium aurantiogriseum and lovastatin by Aspergillus terreus: determination of the origin of carbon, hydrogen and oxygen atoms by 13C NMR spectrometry and observation of unusual labelling of acetate-derived oxygens by 18O2

5. Putative Diels Alder catalyzed cyclization during the biosynthesis of lovastatin;Witter;J. Org. Chem.,1996

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